In the autumn of 1958, the Wiesbaden Chamber Orchestra appeared on concert programs for the first time. A circle of musicians had already come together during their music studies to cultivate the Musica Sacra.

Under the direction of its conductor Carl Witzel, this string ensemble played regularly in various churches in Wiesbaden and the surrounding area from 1950 onwards. Soon they were also giving concerts at the Wiesbaden Casino Society, the Wiesbaden Kurhaus and Mainz Palace. At the annual Advent concerts in Eppstein, the orchestra performed with internationally renowned soloists such as the violinist Wolfgang Schneiderhahn and the cellist Enrico Mainardi. In 1962 and 1963, several long-playing records were made that made the orchestra famous beyond the region's borders. From the mid-1960s, the Wiesbaden Chamber Orchestra gave its first concerts at Biebrich Palace.

Helmut May (1929-2013), the orchestra's concertmaster for many years, and Carl Witzel wrote several compositions for the Wiesbaden Chamber Orchestra that attracted a great deal of attention. The Wiesbaden Chamber Orchestra worked closely with the Carl Witzel Choir Association, which was founded in 1958, and in 2010 the church musician Franz Josef Oestemer took over the direction of the orchestra.