The new synagogue was built by architects Ignaz Jakubowitz and Helmut Joos from Frankfurt following the demolition of the synagogue of the old Israelite community in Friedrichstraße. Previously, the synagogue, which had been desecrated by the Nazis during the Reichspogromnacht but not set on fire, had served as a house of prayer for the newly founded Jewish community at the end of 1946.

The foundation stone was laid on 04.04.1965 and the official opening ceremony took place on 11.09.1966 in the presence of the Hessian Minister President Georg August Zinn. State Rabbi Lichtigfeld gave the ceremonial address. The long-standing community chairman Dr. Friedrich Reichmann, the actual initiator of the new building, did not live to see the inauguration ceremony.

The simple new synagogue building consists of a small vestibule with a U-shaped women's gallery and the rounded sanctuary. In addition to the prayer room, there are adjoining rooms for the rabbi and liturgical equipment as well as the library. The dominant element in the interior are two colored windows, each 40^m2 in size, created by the Wiesbaden sculptor and glass designer Egon Altdorf. Both show the first letter of God's name (Shin) in Hebrew script, the shield of David (Star of David) and the characters and symbols of the twelve tribes of Israel. The window of praise is dominated by a monumental harp motif on a bright red and yellow background. A counterpart to this is the window of the covenant, which is entirely in deep blue. The eye-catcher inside the synagogue is the Ner Tamid, the Eternal Light, inserted into a round, "winged" pane of glass, which reproduces a shortened form of the Ten Commandments and is suspended freely in the middle of the sanctuary above the Torah shrine.

Between the synagogue and the seven-storey office building on Friedrichstrasse is a three-storey intermediate building with offices, meeting rooms and a janitor's apartment. The Jewish community, which has almost 800 members, has thus found a lively center in Wiesbaden.