In 1879, the "Herberge zur Heimat", a house with 10 beds for hikers and three guest rooms for needy people, took in wandering craftsmen and workers. The Evangelical Association for Inner Mission acquired the facility and the entire site and erected a new building with over 40 rooms and 95 beds. Further extended in 1907-10, the new "Christian Hospice" was geared towards the needs of an upmarket clientele.

During the First World War, it served as a military hospital and as accommodation for people in need. Soon afterwards, it was modernized again and was a convalescent home for several years. The facility was hardly damaged during the Second World War. In the post-war years, refugees and elderly people who had become homeless found a place to stay here.

At the beginning of the 1960s, the building was once again used as a hotel. A modern new building with a large meeting room, the "Oraniersaal", suitable for conferences and gatherings of up to 100 people, was added to the older wing. Today's hotel has 87 individually furnished rooms. The only reference to the hotel's original purpose is a figure on the exterior façade depicting a journeyman on his travels.

The hotel, which has only been called Hotel Oranien since 1969, is a member of the Association of Christian Hospices (VCH), which was founded in 1904.