In 1891, a residential home for the Red Cross nurses was built on a site acquired by the Wiesbaden Red Cross Association on the Leberberg at the Schöne Aussicht in 1889, followed by the Red Cross hospital with 42 beds and a nursing school in 1892. In the following years, a home for women who had recently given birth and a new operating theater were added. During the First World War, the Red Cross Hospital was used as a surgical hospital and as a maternity asylum for soldiers' wives in need of help.

The decision taken in the mid-1930s to build a new Red Cross hospital, which had grown to 120 beds, was prevented by the Second World War and was not taken up again until 1951. Finally, the old building was renovated and an extension wing with three modern operating theaters, two delivery rooms, a laboratory and several offices was inaugurated in the mid-1950s. The number of beds rose to 130.

Since the turn of the millennium, financial difficulties have become more frequent; in 2005, the hospital was closed and the Red Cross Hospital was converted into a health center with an affiliated private clinic, which is run by the Oranien Red Cross Nurses' Association.