Since 01.07.1884, the Red Crosses had been active in caring for the poor in the city of Wiesbaden. On 17.06.1885, the Wiesbaden Red Cross Association for the Training and Use of Nurses was founded, to which the Red Crosses belonged from then on as registered associations.

From April 1894, 17 nurses were employed in the municipal hospitals. As numerous nurses were also employed outside Wiesbaden in the following years, additional auxiliary staff had to be engaged from 1899 onwards. During the First World War, 66 women were involved in war nursing. During the Second World War, over 200 nurses and over 400 auxiliary nurses worked in mobile units of the Wehrmacht, the Wehrmacht medical service and in reserve hospitals.

At the 50th anniversary celebrations on 29.07.1935, the association was given the name German Red Cross, Oranien Sisterhood, which the Wiesbaden Sisterhood also joined in 1958. In 1958, the Oranien Red Cross Sisterhood took over nursing care in the municipal women's clinic at Bahnholz.

In the mid-1970s, the Red Cross Oranien Sisterhood consisted of 116 nurses, 134 trainee nurses and 110 retired nurses. Today, the association has around 200 members who work as nurses, pediatric nurses, geriatric nurses, midwives, nursing educators and nursing specialists.