On the initiative of several American women, ten American and eleven German women founded the "German-American Women's Club" on March 17, 1949. The American military government attached particular importance to the role of German women in the democratization of the country. The founders formulated the goals of the club as mutual understanding, cultural exchange of ideas, interest in tasks of public life, the reduction of prejudices and the deepening of mutual relations. The first task was to overcome language difficulties and establish personal contact between the members.

In addition to social and private meetings, the members also wanted to get involved in social causes. In 1949, for example, the club organized a Christmas party for 5,000 needy Wiesbaden children in the Kurhaus, and the following year it held the Pfennigparade, the "March of Dimes", the proceeds of which benefited children suffering from polio. Since the 1960s, the women have been organizing flea markets and bazaars to raise money for charitable causes. The proceeds benefit the German-American Student Exchange, the youth program and other social institutions in the city and the Americans living here. After the composition of the club changed and women from a total of 16 nations came together, the club name was changed to "German-American and International Women's Club Wiesbaden" in 2008.