The collection point was the synagogue in Friedrichstraße, which was desecrated in 1938. From there, the Jews were taken to the slaughterhouse to be deported by train.

Before the last of these deportations alone, 40 Jews from Wiesbaden had committed suicide; probably well over 100 died by suicide during this time. While there were barely more than 1,000 "full Jews" registered in Wiesbaden at the beginning of the year, their number had dwindled to just 177 by the end of 1942; ten years earlier, over 3,000 people of the Jewish faith had lived here. Finally, the Jews living in "mixed marriages" and their children were also deported, most recently on February 18, 1945. After the liberation from Nazi fascism, only about a dozen Holocaust survivors returned to Wiesbaden.

Wiesbaden's Sinti also fell victim to the Nazi genocide: of the Sinti arrested here on March 8 and deported to Auschwitz-Birkenau the following day, it is estimated that more than two thirds perished.