Wilhelmstrasse is the boulevard of the Hessian state capital. Designed by Christian Zais, the boulevard is lined with houses on one side and the Warmen Damm park on the other. Numerous boutiques and furniture stores have settled along the rue.

Also located along Wilhelmstraße are the Erbprinzenpalais - today the seat of the Wiesbaden Chamber of Industry and Commerce - the Kurhaus, the Hessisches Staatstheater Wiesbaden and the Hotel Nassauer Hof.

Wilhelmstraße runs from Kureck to Rheinstraße and thus forms the eastern boundary of the historic pentagon.